Claiming God commanded her to
gruesomely murder her three small children, a radical political-science
professor with a high-profile politician husband pleads insanity, leaving New
York District Attorney Roger "Butch" Karp the arduous—and incredibly unpopular—task
of proving that she's not. Meanwhile, an American-born jihadist detonates a
suicide bomb inside a Manhattan synagogue. A harrowing question links the
violent crimes: Is there any defense for a killer who believes that committing
murder is God's will?

As Karp, his wife Marlene, their
daughter Lucy, and a cast of eccentric accomplices begin a deadly manhunt, they
uncover an intricate terrorist plot to paralyze New York's emergency response
system and cripple the economy. They must find an assassin known only as "The
Sheik" before he orchestrates a bloody massacre that could devastate the
country forever.