The death of Sir Edward Crick has unleashed a torrent of gossip through the seedy taverns and elegant ballrooms of Oxfordshire. Few mourn the dissolute young man- except his sister, the beautiful Lady Lydia Farrell. When her husband comes under suspicion of murder, she seeks expert help from Dr. Thomas Silkstone, a young anatomist from Philadelphia. Thomas arrived in England to study under its foremost surgeon, where his unconventional methods only...

As the streets of 18th-century Oxfordshire swirl with rumors of an evil and all-consuming "great fog," Sr. Thomas Silkstone arrives at the estate of Lady Lydia Farrell, where nearly everything is at risk.

In an effort to free his intimate friend, Lady Lydia Farrell, from a mental hospital, Dr. Thomas Silkstone seeks out the custodian of her affairs at Boughton estate, where two murders lead Dr. Silkstone to discover a sinister conspiracy.