First a meth lab on wheels explodes into the San Francisco night, bringing detective LIndsay Boxer rushing to the scene. Later, she and her lover, Joe Molinari, are interrupted by reporter Cindy Thomas, who has come upon the body of an itinerant preacher, known for his kindness. It isn't until a glamorous, wealthy couple is killed in their home - with not a trace of evidence left behind - that Lindsay begins to wonder, crazy as it seems, whether all these deaths are connected. One connection that can't be missed is the one sizzling between Cindy and Rich Conklin, LIndsay's rugged partner, as the women of the Murder Club join forces.